efflux pump造句

• Some types of efflux pumps can act to decrease intracellular quinolone concentration.
• Deletion of the gene encoding the multidrug efflux pump Pdr5 sensitizes cells to puromycin.
• The TetA protein is an efflux pump.
• Efflux pumps are one of the major causes of anticancer drug resistance in eukaryotic cells.
• During the last 40 years, many trials for constructing effective " multidrug efflux pumps.
• Zosuquidar inhibits P-glycoproteins, inhibiting the efflux pump and restoring sensitivity to chemotherapeutic agents.
• Low-level quinolone resistance has been linked to changes in cell permeability and efflux pumps.
• Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae.
• The NorM efflux pump is encoded by the " norM " gene and provides resistance to fluoroquinolones.
• This compound shows moderate activity as an efflux pump inhibitor against multidrug-resistant " Staphylococcus aureus ".
• However, it is not yet known whether goldenseal contains a drug resistance efflux pump inhibitor, although many antimicrobial herbs do.
• Because most antibiotics are amphiphilic molecules-possessing both hydrophilic and hydrophobic characters-they are easily recognized by many efflux pumps.
• Sirolimus is metabolized by the CYP3A4 enzyme and is a substrate of the P-glycoprotein ( P-gp ) efflux pump.
• P-glycoprotein is the best-studied efflux pump and as such has offered important insights into the mechanism of bacterial pumps.
• Efflux systems function via an energy-dependent mechanism ( active transport ) to pump out unwanted toxic substances through specific efflux pumps.
• Persister cells in " E . coli " can transport intracellular accumulations antibiotic using an energy requiring efflux pump called TolC.
• ArsD transfers trivalent metalloids to ArsA, the catalytic subunit of an As ( III ) / Sb ( III ) efflux pump.
• The MDR response is due to an  overexpression of drug efflux pumps the ATP-binding cassette family and the major facilitator superfamily.
• "B . pseudomallei " is intrinsically resistant to a large number of antimicrobial agents by virtue of its efflux pump mechanism.
• The "'YkkC / YxkD leader "'is a efflux pumps and detoxification systems in response to harmful environmental molecules.